The data pertains to research projects related to antimicrobial resistance control, supported by the Health and Medical Research Fund (HMRF). For information on individual projects,* please refer to the website: https://rfs.healthbureau.gov.hk/app/fundedsearch/basicsearch.xhtml?lang=en
| Year of announcement of open call | Number of projects | ||
|---|---|---|---|
| Innovative technology and medical science | Behavioural science and psychology | Health and economic burden | |
| 2012 | 11 | 1 | 0 |
| 2013 | 13 | 0 | 0 |
| 2014 | 5 | 0 | 0 |
| 2015 | 5 | 0 | 1 |
| 2016 | 2 | 0 | 2 |
| 2017 | 7 | 1 | 0 |
| 2018 | 5 | 0 | 0 |
| 2019 | 7 | 0 | 0 |
| 2020 | 13 | 0 | 0 |
| 2021 | 11 | 0 | 0 |
| 2022 | 6 | 2 | 1 |
| 2023 | 5 | 0 | 0 |
* Information on individual projects:
1. Innovative technology and medical science
| Reference number | Project title |
| 13120062 | Novel antibacterial actions of vitamin D and butyrate in Helicobacter pylori infection: Involvement of cathelicidin and autophagy |
| 13120122 | Structure-based discovery of inhibitors of Helicobactor pylori urease maturation |
| 13120272 | Enhancing antibiotics efficacy by combinations of active ingredients from Traditional Chinese Medicine against methicillin-resistant Staphylococcus aureus |
| 13120302 | Photodynamic therapy mediated by natural products on methicillin-resistant Staphylococcus aureus (MRSA)-infected wound |
| 13120432 | Elucidation of drug resistance mechanism by whole genome sequencing of Mycobacterium tuberculosis spontaneous mutants |
| 13120722 | Characterization of two-component system mutants responsible for silver resistance and its implication in resistance development in pathogenic bacteria |
| 13120862 | Characterization of Staphylococcus aureus virulence factor EsxA and structure-based screening of EsxA's inhibitors for combating methicillin-resistant Staphylococcus aureus (MRSA) |
| 13121042 | Molecular characterization of antibiotic resistance in Staphylococcus lugdunensis isolates |
| 13121182 | Development of daptomycin-based next-generation antibiotics to combat multidrug-resistant bacteria |
| 13121422 | Molecular mechanisms of fluoroquinolone and expanded-spectrum cephalosporin resistance in Vibrio parahaemolyticus |
| 13121502 | Understanding the small RNA-regulated dissemination of emerging multidrug resistant mobile elements in Hong Kong |
| 14130052 | Biological crystal subunit vaccines for mycobacterial diseases |
| 14130102 | Molecular screening for community‐based cephalosporin‐resistant Neisseria gonorrhoeae in key populations in Hong Kong |
| 14130362 | Delineation of therapeutic potential and the causal relationship between Vitamin D and Helicobacter pylori (HP) infection and gastritis |
| 14130402 | Characterization the role of OqxAB in Salmonella virulence and antimicrobial resistance |
| 14130422 | Mechanism of substrate recognition and specificity of B2 and B1 subclasses of metallo-β-lactamases：insights into their different spectrums of substrate specificity |
| 14130432 | Development of novel tridenate inhibitors targeting to active site residues and Zinc ions of New Delhi Metallo β-lactamases-1 (NDM-1) |
| 14130502 | A pilot study of structure-based modification of Cephalosporin C to enhance resistance against extended-spectrum β-lactamases |
| 14130532 | RNomics study of the emerging incompatibility group X3 plasmid carrying blaNDM-1 in Hong Kong |
| 14130702 | Exploring the role of the gram-negative bacterial general efflux protein TolC in biofilm formation in Escherichia coli |
| 14130722 | Molecular epidemiology of transferrable multidrug-resistant pump oqxAB in Escherichia coli from human and animal sources |
| 14130742 | A feasibility study on the inhibition of Staphylococcus aureus infection using AdsA specific antibodies |
| 14130782 | A double-blind randomized controlled trial of 13-valent pneumococcal conjugated vaccine in patients with chronic illness |
| 14131142 | Host target characterizations for early secreted virulence factors ESAT6/CFP10 of Mycobacterium tuberculosis and structure-based screening of ESAT6/CFP10 's inhibitors for combating multi-drug resistant tuberculosis (MDR-TB) |
| 15140252 | A novel anti-microbial crystal for the treatment of Helicobacter pylori infection |
| 15140322 | Development of smart theranostic agents for imaging and photoinactivation of beta-lactamase-producing bacteria |
| 15140342 | Unveiling the disseminative characteristics and bacterial fitness of major multidrug resistance plasmids by Genomics and RNomics analysis |
| 15140992 | Structural study of NDM-1: Towards rational inhibitor design against the antibiotic resistant “superbug” |
| 15141322 | Re-defining the molecular basis of carbapenem resistance in clinical Acinetobacter baumannii isolates |
| 16150072 | Rapid and comprehensive prediction of first and second-line drug resistance in Mycobacterium tuberculosis directly from respiratory specimens using massive parallel targeted sequencing: A prospective study |
| 16150422 | Virus-like particle (VLP)-based mucosal vaccine for inducing cross-serotype immunity against Streptococcus pneumoniae infection |
| 16150942 | The role of vraSR two-component system in methicillin-resistant Staphylococcus aureus skin and soft tissue infections |
| 16151172 | Activating mucolipin for restoring lysosomal function in the control of Helicobacter pylori colonization |
| 16151202 | Development of a new class of photosensitizers, cationic boron dipyrromethenes, for the photodynamic therapy on methicillin-resistant Staphylococcus aureus infection |
| 17160152 | Development and evaluation of novel synthetic bacterial ribosomal RNA transcription inhibitors as antimicrobials against methicillin-resistant Staphylococcus aureus (MRSA) |
| 17160212 | Dissecting human and animal Streptococcus agalactiae (Group B streptococcus) and its resistance determinants through territory-wide sampling |
| 18170082 | Resistome of gut microbiota and modulation in healthy Hong Kong population |
| 18170092 | Elucidation of the role of cathelicidin in protection against multi-drug resistant Acinetobacter baumannii associated pneumonia |
| 18170262 | Preclinical study of nanoparticle-formulated vaccine against invasive staphylococcus aureus infection |
| 18170512 | The identification of protective epitopes of a protein vaccine Sta-C9 against Methicillin-resistant Staphylococcus aureus (MRSA) infection and design of a novel multi-epitope vaccine |
| 18170572 | A new class of antimicrobial therapeutics that targets the envelope stress response of Gram-negative bacteria |
| 18170972 | Novel inhalable powder formulations of synergistic combinations of antimicrobial peptides and antitubecular drugs to combat both drug-sensitive and multidrug-resistant tuberculosis |
| 18171042 | Delineating the efflux protein TolC mediated hyper-biofilm formation in uropathogenic E. coli and their exploitations in the dual control of biofilm and antibiotic resistance |
| 19180052 | The effects of novel synthetic antimicrobial agents on the pathogenicity of methicillin-resistant Staphylococcus aureus (MRSA) |
| 19180062 | Hydrogel delivery of vancomycin and DNase I to eradicate osteosynthesis-associated methicillin-resistant Staphylococcus aureus (MRSA) Infection and support osteoporotic fracture healing |
| 19180162 | Targeting H3K27me3 by EZH2 inhibitors in control of drug-resistant Helicobacter pylori colonization |
| 19180692 | Decrypting the mechanism of anti-virulence compound HR3744 against MRSA by targeting the response regulator SaeR |
| 19180712 | Investigation of a double-coated titanium implant with near-infrared controlled antimicrobial capabilities for photodynamic and photothermic therapy |
| 20190032 | Antimicrobial activities of the novel bacterial transcription inhibitor against methicillin-resistant Staphylococcus aureus (MRSA) |
| 20190102 | Inhaled endolysin therapy against ‘superbug’ lung infections |
| 20190302 | A pilot study evaluating Edaravone as anti-biofilm agent in treating bacterial infections |
| 20190422 | Investigation of photothermally responsive multi-layered graphene oxide coating for controlled release of antibacterial reagents to act against orthopaedic implant-related infection |
| 20190442 | Synthesis of novel multifunctional nanocomposites based on biosurfactant coated Ag-MNPs/teixobactin analogues for enhanced biofilm disruption and bacteria elimination |
| 20190682 | Novel injectable hydrogels encapsulated with bismuth-doped carbon dots-based nanomedicine for periodontal treatment and healthcare via antimicrobial & immuno-modulatory approaches |
| 20190802 | Development of synthetic carbohydrate-based antibacterial vaccines against Gram-negative bacteria |
| 19200861 | Characterisation of heteroresistance in commensal Escherichia coli isolates in relation to therapeutic use of antibiotics |
| 19201901 | Genome-based antibiotic resistance predictions with deep learning |
| 21200092 | Establishment of clinical workflow for rapid identification of pathogens and antimicrobial resistance from infected body fluids – Metagenomic vs targeted amplicon sequencing approach |
| 21200142 | Predicting empirical choice of susceptible antibiotics in urinary tract infection with machine learning algorithms |
| 21200182 | Antibiotic stewardship through CRP-guided antibiotic treatment for patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) |
| 21200512 | First detection of pandemic clone Salmonella ST34-carrying mcr-3: prevalence and characteristics of multidrug resistant Salmonella in humans and foods in Hong Kong |
| 21200582 | Pilot study on zoonotic pathogens and antimicrobial resistance associated with food fish in Hong Kong fish markets |
| 21200592 | Investigation of hydrogel dressing materials with embedded photoresponsive carbon quantum dots/zinc oxide (CQDs/ZnO) antibacterial nanostructures for the treatment of wound infections |
| 21200752 | Evaluation of chemical inhibitors targeting the interaction between bacterial RNA polymerase and transcription factor NusA as novel antimicrobial agents against methicillin-resistant Staphylococcus aureus (MRSA) |
| 21200772 | Improving the therapeutic index of melittin to eradicate drug-resistant Acinetobacter baumannii |
| 21200782 | Pulmonary delivery of engineered endolysin to treat Gram-negative bacterial pneumonia |
| 21200822 | Carnobacterium maltaromaticum as a novel probiotic treatment for attenuating gut barrier dysfunction and systemic inflammation in sepsis |
| 21200972 | Biocompatible titanium implants with antibacterial capability arising from the synergistic effects of mechanical and electrical interactions and quantitative bacteria sensing ability based on electron transfer |
| 22210032 | Elucidating the role and therapeutic potential of RNA N1-methyladenosine (m1A) modification in sepsis |
| 22210142 | Combating implant infections: An approach with polydopamine-assisted surface coating of phage-derived depolymerases |
| 22210282 | Mycoplasma genitalium infection and associated antimicrobial resistance among HIV-infected male in Hong Kong |
| 22210412 | Investigation of unnatural amino acid-based diseleno derivatives as the target-specific covalent inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1) |
| 22210432 | Circulating small RNA-based diagnostics for differentiation of Candida species in candidemia |
| 22210712 | Development of novel vaccine candidate and passive immunotherapy against multidrug-resistant hypervirulent Klebsiella pneumoniae |
| 22210782 | Developing a novel multi-functionalised graphene oxide nanocomposite for arresting dental caries |
| 22210832 | Photo-induced zinc-doped graphite-crystalline phase carbon nitride-based (CN-Zn/BiS) nanostructures on titanium surface enabling in situ bacterial killing and implant-to-bone integration |
| 22210942 | Development of arginine-based synbiotics for oral biofilm modulation and caries prevention |
| 22211072 | Development of bithionol analogues as β-Lactamase inhibitor for clinical treatment of infections caused by Enterobacteriaceae strains carrying Class B1 Metallo-β-Lactamases |
| 22211142 | Investigation and development of the antisense oligonucleotides targeting plasmid-encoded RNA binding protein as the adjuvant to reduce the fitness of drug resistant bacteria |
| 23220372 | Developing Juglone as a novel antivirulence agent to eliminate biofilm infections |
| 23220752 | Novel engineered ultrasound-responsive titanium-carbide based antibacterial nanostructures on titanium surface enabling efficient sonodynamic bactericidal capability and superior bone-to-implant integration |
| 23220312 | AI models helping combat antibiotic resistance in ICU – personalized decision support for empirical antibiotic therapy |
| 23220722 | Characterizing a monoclonal antibody toolkit for pan-hepatitis E virus diagnostics and therapeutics |
| 23220952 | Sonodynamic-mediated microneedle array engineered with modified zinc-based metal-organic framework (MOF) antibacterial nano-particles enabling subcutaneous administration for wound infection |
| 23220102 | Functioning sprayable hydrogel with antimicrobial peptide coupled mesoporous polydopamine nanoparticles for infected chronic wound management |
| 24230372 | Development and Validation of Risk Scores Using Machine Learning Algorithms to Determine Empirical Antibiotics Therapy for Community-acquired Pneumonia |
| 24230162 | A genetically encoded bio-responsive antimicrobial crystal for the improved eradication of antibiotic-resistant H. pylori and restoration of gut dysbiosis |
| 24230402 | Application of Targeted Capture Sequencing for Diagnosis of Respiratory Infections – Simultaneous Pathogen Identification, Antimicrobial Resistance Gene Detection and Strain Typing in a Single Reaction |
| 24231112 | Novel ultrasound-responsive antibacterial surface structure on metal implant enabling rapid eradication of MRSA biofilm via mutual sonodynamic and sonothermal effects |
| 24230142 | Antimicrobial Activity of Novel Small Molecule Antimicrobial Agents Targeting Bacterial Transcription Initiation against Clinical MRSA Strains from Blood Specimens at the Prince of Wales Hospital |
2. Behavioural science and psychology
| Reference number | Project title |
| 13121452 | An evaluation of a simplified 5-step hand hygiene intervention program for students with mild grade intellectual disability in a special school |
| 18170312 | Acquisition of multidrug resistant organisms among travelers in Hong Kong: prevalence, determinants and persistence |
| 23221102 | A cluster-randomized controlled pragmatic trial to evaluate antimicrobial stewardship strategies for short-course and oral-switch antibiotic therapy for bloodstream infections due to Enterobacterales |
| 23220402 | Risk assessment and surveillance of the transmission of foodborne antimicrobial resistance in Hong Kong |
3. Health and economic burden
| Reference number | Project title |
| 16151082 | The first Hong Kong study to explore prevalence and risk factors for the emergence of antibiotic resistant Mycoplasma genitalium(MG) among sexually transmitted infection(STI) male patients |
| 17160302 | A longitudinal study of carriage prevalence of antimicrobial resistance in general population in Hong Kong |
| 17161342 | Surveillance of environmental contamination by antibiotics and antibiotic resistant pathogens |
| 23221022 | Multicentre study on the emerging resistance of Clostridioides difficile to metronidazole in Hong Kong |