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Frequently Asked Questions on Seasonal Influenza Vaccine for the 2019/20 Season in Hong Kong

Frequently Asked Questions on Seasonal Influenza Vaccine for the 2019/20 Season in Hong Kong

2019-09-01

A. Influenza

  1. What is influenza?
  2. What is the difference between seasonal and pandemic influenza?
  3. Why is seasonal influenza vaccination important?

B. People who should receive seasonal influenza vaccination

  1. Who should receive seasonal influenza vaccination?
  2. Who should have higher priority for seasonal influenza vaccination?
  3. I do not belong to any recommended priority group for 2019-20 seasonal influenza vaccine. Should I receive 2019-20 seasonal influenza vaccine?
  4. Why should pregnant women receive seasonal influenza vaccination?
  5. Why should obese persons (body mass index [BMI] 30 or above) receive seasonal influenza vaccine?
  6. Why should persons aged 50 or above receive seasonal influenza vaccine?
  7. Why should healthcare workers (HCWs) receive seasonal influenza vaccine?
  8. Why should poultry industry workers receive seasonal influenza vaccine?
  9. Why should pig farmers and pig-slaughtering personnel receive seasonal influenza vaccine?
  10. Why children aged 6 months to 11 years are recommended to receive seasonal influenza vaccine?

C. Seasonal influenza vaccine

  1. What is the recommended composition of the 2019-20 seasonal influenza vaccine?
  2. What types of seasonal influenza vaccines are recommended for use in Hong Kong by SCVPD?
  3. What are the differences between inactivated influenza vaccine (IIV) and live attenuated influenza vaccine (LAIV)?
  4. Who should not receive inactivated influenza vaccine (IIV)?
  5. Who should not receive live attenuated influenza vaccine (LAIV)?
  6. My child has asthma. Should he avoid the influenza vaccination in case it gives him an attack?
  7. What are the possible side effects of the inactivated influenza vaccine?
  8. What are the possible side effects of live attenuated influenza vaccine (LAIV)?
  9. What is Guillain-Barré syndrome (GBS)? Can influenza vaccination cause GBS?
  10. Can I receive seasonal influenza vaccine if I had history of Guillain-Barré syndrome (GBS)?
  11. Does seasonal influenza vaccine cause influenza?
  12. Is the seasonal influenza vaccine safe for breastfeeding mothers and their infants?
  13. Do the influenza vaccines in Hong Kong contain a mercuric compound or aluminum?

D. Vaccine administration

  1. Does the seasonal influenza vaccine work right away?
  2. When should I get vaccinated?
  3. How much protection does the seasonal influenza vaccine provide?
  4. Is it necessary to get vaccinated against seasonal influenza every year?
  5. How many doses of seasonal influenza vaccination will my child need?
  6. If a child under the age of 9 years is getting seasonal influenza vaccine for the first time and requires 2 doses, does the same type of vaccine have to be used for both doses?
  7. Can pneumococcal vaccines be given together with seasonal influenza vaccine?
  8. Can seasonal influenza vaccine be given together with Measles, Mumps and Rubella (MMR) vaccine?
  9. Can my child receive the seasonal influenza vaccination if he / she has received / will receive other immunisation?
  10. Why do some people who have been vaccinated still get influenza / influenza-like illness?

A. Influenza

1. What is influenza?

Influenza is an infectious viral disease. It can be caused by various types of influenza viruses. In Hong Kong, the two subtypes of influenza A virus, H1N1 and H3N2, and influenza B virus, are most commonly seen. Influenza occurs in Hong Kong throughout the year, but is usually more common in periods from January to March/April and from July to August. The virus mainly spreads by respiratory droplets. The disease is characterised by fever, sore throat, cough, headache, muscle aches, runny nose and general tiredness. It is usually self-limiting with recovery in two to seven days. However, if persons with weakened immunity and elderly persons get infected, it can be a serious illness and may be complicated by bronchitis, pneumonia or even death in the most serious cases. Serious influenza infection can also occur in healthy individuals.

2. What is the difference between seasonal and pandemic influenza?

Seasonal influenza refers to the viruses that circulate in the human population and cause widespread illnesses especially during each influenza season. Pandemic influenza occurs rarely, when a new influenza virus emerges which is markedly different from those already circulating in the human population. It causes disease in people and spreads easily between people because they have little or no immunity to it.

3. Why is seasonal influenza vaccination important?

Seasonal influenza vaccination is one of the effective means to prevent seasonal influenza and its complications, as well as reduce influenza related hospitalisation and death.

B. People who should receive seasonal influenza vaccination

4. Who should receive seasonal influenza vaccination?

Given that influenza vaccines are safe and effective and severe cases can occur even in healthy persons, all members of the public aged 6 months or above, except those with known contraindications, should receive seasonal influenza vaccine for personal protection.

5. Who should have higher priority for seasonal influenza vaccination?

People who are in the priority groups are generally at increased risk of severe influenza or transmitting influenza to those at high risk. Therefore, they should have higher priority for seasonal influenza vaccination.

In the 2019-20 season, the Scientific Committee on Vaccine Preventable Diseases (SCVPD) recommends the following priority groups for seasonal influenza vaccination in Hong Kong:

  • Pregnant women
  • Elderly persons living in residential care homes
  • Long-stay residents of institutions for persons with disability
  • Persons aged 50 years or above
  • Persons with chronic medical problems*
  • Healthcare workers
  • Children between the age of 6 months to 11 years
  • Poultry workers
  • Pig farmers and pig-slaughtering industry personnel
* People with chronic medical problems mainly refer to those who have chronic cardiovascular (except hypertension without complication), lung, metabolic or kidney diseases, obesity# (Body mass index [BMI] 30 or above), who are immunocompromised^, children and adolescents (aged 6 months to 18 years) on long-term aspirin therapy, and those with chronic neurological condition that can compromise respiratory function or the handling of respiratory secretions or that can increase the risk for aspiration or those who lack the ability to care for themselves.

# Obesity is considered as an independent risk factor for influenza complication and thus people with BMI 30 or above are included in the priority groups for seasonal influenza vaccination.

^ People who are immunocompromised refer to those with a weakened immune system due to disease (such as HIV/AIDS) or treatment (such as cancer treatment).

Members of the public can consult their family doctors to receive seasonal influenza vaccination for personal protection.

6. I do not belong to any recommended priority group for 2019-20 seasonal influenza vaccine. Should I receive 2019-20 seasonal influenza vaccine?

According to the World Health Organization, when the vaccine strains closely match the circulating influenza viruses, efficacy of influenza vaccine in individuals younger than 65 years of age typically range from 70% to 90%. Given that severe cases do occur in previously healthy persons, all members of the public aged 6 months or above, except those with known contraindications, should receive seasonal influenza vaccine for personal protection. Members of the public can consult their family doctors to receive seasonal influenza vaccination for personal protection.

7. Why should pregnant women receive seasonal influenza vaccination?

Influenza vaccination in pregnant women has shown benefits for both mother and child in terms of reduced acute respiratory infections. The World Health Organization considers inactivated influenza vaccine (IIV) to be safe in pregnancy and there is no evidence showing that IIV can cause abnormality in foetus even if given during the first trimester. However, pregnant women should NOT receive live attenuated influenza vaccine because it contains live viruses. Pregnant women should consult a doctor for any queries.

8. Why should obese persons (body mass index [BMI] 30 or above) receive seasonal influenza vaccine?

Local and overseas evidence suggested that obesity is an independent risk factor for severe influenza A(H1N1)pdm09 infection including intensive care unit admission or death. As the influenza A(H1N1)pdm09 virus is a common type of seasonal influenza virus, obese individual with BMI 30 or above is regarded as having a high-risk condition and is therefore recommended for influenza vaccination.

9. Why should persons aged 50 or above receive seasonal influenza vaccine?

Persons aged 50-64 should receive seasonal influenza vaccination because local influenza epidemiology showed that people aged 50–64 years, irrespective of high-risk conditions, were having a higher risk of intensive care unit admission and death associated with influenza A(H1N1)pdm09 infection. Influenza A(H1N1)pdm09 is a common type of seasonal influenza virus.

The SCVPD recommends seasonal influenza vaccination for elderly persons aged 65 years or above because of their high risk of complications, excess hospital admissions and death from influenza.

10. Why should healthcare workers (HCWs) receive seasonal influenza vaccination?

The SCVPD recommends HCWs to receive seasonal influenza vaccination to reduce morbidity and hence reduce absenteeism among healthcare workers related to respiratory infections. Seasonal influenza vaccination of HCWs can also reduce the risk of transmitting influenza to patients who are at high risk of complications and mortality from influenza.

11. Why should poultry industry workers receive seasonal influenza vaccine?

Poultry industry workers have higher chance of contacting avian influenza viruses. Influenza vaccination can prevent seasonal influenza in humans, and hence minimise the chance of concomitant infections of human seasonal influenza and avian influenza viruses in humans. This in turn minimise the risk of genetic re-assortment and eventual emergence of a novel influenza A virus.

12. Why should pig farmers and pig-slaughtering industry personnel receive seasonal influenza vaccine?

Researchers previously detected influenza A(H1N1)pdm09 (formerly known as Human Swine Influenza) viruses in pigs sampled in Hong Kong. Local experts considered that the influenza A(H1N1)pdm09 virus detected in pigs was transmitted from humans to pigs. Swine influenza viruses circulating in pigs might infect humans in rare occasions. Influenza vaccination of the pig-related industry workers can prevent seasonal influenza among them, and hence minimise the chance of concomitant infections of human seasonal influenza and swine influenza viruses in either humans or pigs. This in turn minimise the risk of genetic re-assortment and eventual emergence of a novel influenza A virus.

13. Why children aged 6 months to 11 years are recommended to receive seasonal influenza vaccine?

Seasonal influenza vaccination is recommended for children 6 months to 11 years for reducing influenza related complications such as excess hospitalisations or deaths. Studies in overseas have shown that vaccinating young school children may potentially reduce school absenteeism and influenza transmission in the community.

C. Seasonal influenza vaccine

14. What is the recommended composition of the 2019-20 seasonal influenza vaccine?

The quadrivalent influenza vaccine recommended by the SCVPD for the 2019-20 season contains the following:

  • an A/Brisbane/02/2018 (H1N1)pdm09-like virus
  • an A/Kansas/14/2017 (H3N2)-like virus
  • a B/Colorado/06/2017-like virus
  • a B/Phuket/3073/2013-like virus

If trivalent influenza vaccine is being used, the influenza B component shall contain a B/Colorado/06/2017-like virus.

15. What types of seasonal influenza vaccines are recommended for use in Hong Kong by SCVPD?

Both inactivated influenza vaccine (IIV) and live attenuated influenza vaccine (LAIV) are recommended for use in Hong Kong by SCVPD. For IIVs, quadrivalent IIV is preferred to trivalent IIV due to the additional protection against one more lineage of influenza B offered by quadrivalent IIV. Depending on individual brand, IIVs are recommended for use among people aged six months of age or older, including those who are healthy, pregnant women and those with chronic medical problems. For LAIV, which is a quadrivalent vaccine, it can be used for people 2-49 years of age except those who are pregnant, immunocompromised or with other contraindications (please refer to Question 18 for details). The package inserts for individual products should always be referred to when deciding which vaccine to give.

16. What are the differences between inactivated influenza vaccine (IIV) and live attenuated influenza vaccine (LAIV)?

The IIV contains dead viruses and is given by injection, while LAIV contains weakened viruses and is a nasal-spray vaccine. Both IIV and LAIV are effective, but there are some differences in their indications. Depending on individual product, most IIVs are recommended for use among persons aged 6 months or above, including those who are healthy, pregnant women and those with chronic medical problems. LAIV can be used for people 2-49 years of age except those who are pregnant, immunocompromised or with other contraindications (please refer to Question 18 for details). Please consult your doctor for details.

17. Who should not receive inactivated influenza vaccine (IIV)?

People who have a history of severe allergic reaction to any vaccine component or a previous dose of any influenza vaccine are not suitable to have inactivated seasonal influenza vaccination. Individuals with mild egg allergy who are considering an influenza vaccination can be given IIV in primary care setting. Individuals with a history of anaphylaxis to egg should have seasonal influenza vaccine administered by healthcare professionals in appropriate medical facilities with capacity to recognise and manage severe allergic reactions. Influenza vaccine contains ovalbumin (a chicken protein), but the vaccine manufacturing process involves repeated purification and the ovalbumin content is very little. Even people who are allergic to eggs are generally safe to receive vaccination. Those with bleeding disorders or on anticoagulants should consult their doctors for advice. If an individual suffers from fever on the day of vaccination, the vaccination should be deferred till recovery.

18. Who should not receive live attenuated influenza vaccine (LAIV)?

LAIV is a live vaccine and is generally contraindicated in the following conditions, taking reference from recommendations of the United States, United Kingdom and Canada:

  • History of severe allergic reaction to any vaccine component or after previous dose of any influenza vaccine;
  • Concomitant aspirin or salicylate-containing therapy in children and adolescents;
  • Children 2 years through 4 years who have asthma or who have had a history of wheezing in the past 12 month**;
  • Children and adults who are immunocompromised due to any cause;
  • Close contacts and caregivers of severely immunosuppressed persons who require a protected environment;
  • Pregnancy; and
  • Receipt of influenza antiviral medication within previous 48 hours.

** The UK recommends that vaccination with LAIV should be deferred in children with a history of active wheezing in the past 72 hours or those who have increased their use of bronchodilators in the previous 72 hours.  If their condition has not improved after a further 72 hours then these children should be offered an IIV.  Canada recommends that individuals with severe asthma or those with medically attended wheezing in the 7 days prior to vaccination should not use LAIV.

Individuals with mild egg allergy who are considering an influenza vaccination can be given LAIV in primary care setting. Individuals with a history of anaphylaxis to egg should have seasonal influenza vaccine administered by healthcare professionals in appropriate medical facilities with capacity to recognise and manage severe allergic reactions.  Influenza vaccine contains ovalbumin (a chicken protein), but the vaccine manufacturing process involves repeated purification and the ovalbumin content is very little. Even people who are allergic to eggs are generally safe to receive vaccination. Please consult your doctor for details.

19. My child has asthma. Should he avoid the influenza vaccination in case it gives him an attack?

Children having asthma are not contraindicated to receive inactivated influenza vaccine (IIV). People suffering from lung diseases such as asthma are recommended to receive IIV because of an increased risk of complications associated with influenza. However, children 2 years through 4 years who have asthma or who have had a history of wheezing in the past 12 months should not receive live attenuated influenza vaccine (Please refer to Question 18 for details).

20. What are the possible side effects of the inactivated influenza vaccine?

Inactivated influenza vaccine is very safe and usually well tolerated apart from occasional soreness, redness or swelling at the injection site. Some recipients may experience fever, muscle pain, and tiredness beginning 6 to 12 hours after vaccination and lasting up to two days. If fever or discomforts persist, please consult a doctor. Immediate severe allergic reactions like hives, swelling of the lips or tongue, and difficulties in breathing are rare and require emergency consultation.

Influenza vaccination may be rarely followed by serious adverse events such as Guillain-Barré Syndrome (GBS] (1 to 2 cases per million vaccinees) and severe allergic reaction (anaphylaxis) (9 per 10 million doses distributed). However, influenza vaccination may not necessarily have causal relations with these adverse events. Studies have shown that the risk of GBS after influenza infection (17.20 per million infected persons) is much higher than after influenza vaccination (1.03 per million vaccine recipients).

(The Lancet Infectious Diseases. 2013 Sep; 13(9): 769-76)

21. What are the possible side effects of live attenuated influenza vaccine (LAIV)?

The most common adverse reactions following LAIV administration are nasal congestion or runny nose (in all ages), fever (in children) and sore throat (in adults).  The safety in pregnant women has not been established.  Children aged below five years with recurrent wheezing / persons of any age with asthma may be at an increased risk of wheezing following administration.

22. What is Guillain-Barré syndrome (GBS)? Can influenza vaccination cause GBS?

GBS is a rare neurological disorder causing paralysis and even respiratory difficulties. Most people recover completely but some have chronic weakness. GBS can also develop following a variety of infections, including influenza. So far, there is no conclusive evidence supporting a causal relationship between seasonal influenza vaccine and GBS.

23. Can I receive seasonal influenza vaccine if I had history of Guillain-Barré syndrome (GBS)?

As it is unknown whether influenza vaccination is causally associated with increased risk of recurrent GBS, precaution should be made to ascertain the temporal relationship if there is a history of GBS.

24. Does seasonal influenza vaccine cause influenza?

The viruses in inactivated influenza vaccine are dead viruses, while the viruses in live attenuated influenza vaccine are weakened. Therefore, both vaccines cannot cause influenza. However, a small proportion of people would develop minor side effects after vaccination.

25. Is the seasonal influenza vaccine safe for breastfeeding mothers and their infants?

Yes. Seasonal influenza vaccine is safe for breastfeeding women and their infants. Women who get the flu vaccine while pregnant or breastfeeding can develop antibodies against influenza that can be passed to their infants through their breast milk and provide some protection against flu for infants.

26. Do the influenza vaccines in Hong Kong contain a mercuric compound or aluminum?

No. The influenza vaccines currently supplied for use in Hong Kong do not contain a mercuric compound (e.g. thiomersal) or aluminum.

D. Vaccine administration

27. Does the seasonal influenza vaccine work right away?

No. It takes about two weeks after vaccination for antibodies to develop in the body and provide protection against influenza virus infection. For prevention against influenza, vaccinated individuals should maintain good personal and environmental hygiene practices, balanced diet, regular exercise, adequate rest and no smoking.

28. When should I get vaccinated?

Since it takes about two weeks after vaccination for antibodies to develop in the body and provide protection against influenza virus infection, it is advised to get vaccinated at least two weeks before the start of influenza season. The main influenza season in Hong Kong in the past were the winter season in general, which usually started in January. However, if seasonal influenza vaccination is not received before the winter influenza season, it can still be received as soon as possible.

29. How much protection does the seasonal influenza vaccine provide?

When the vaccine strains closely match the circulating influenza viruses, efficacy of inactivated influenza vaccine (IIV) in individuals younger than 65 years of age typically range from 70% to 90%. For live attenuated influenza vaccine (LAIV), overseas studies and clinical experience had generally indicated LAIV provides comparable protection against influenza to that afforded by IIV. According to data from the United Kingdom, where LAIV has been extensively in use among children aged 2-17 years, the adjusted vaccine effectiveness of LAIV against medically-attended laboratory confirmed influenza among children and adolescents aged 2-17 years was 90% against influenza A(H1N1)pdm09 and 61% against influenza B for the 2017/18 season.

(Public Health England. Influenza vaccine effectiveness in adults and children in primary care in the United Kingdom: provisional end-of-season results 2017-18)

30. Is it necessary to get vaccinated against seasonal influenza every year?

Yes. The circulating seasonal influenza strains may change from time to time. In accordance with the circulating strains, the seasonal influenza vaccine composition is updated every year to enhance protection. The immunity built up in a vaccinated person in the prior season will decrease over time and may become too low to provide protection in the next season. In addition, the vaccine compositions of 2019-20 seasonal influenza vaccine are different from those in 2018-19 season.

31. How many doses of seasonal influenza vaccination will my child need?

To ensure adequate immunity against seasonal influenza, children under 9 years old who have never received any seasonal influenza vaccine are recommended to be given 2 doses of seasonal influenza vaccine with a minimum interval of 4 weeks. Children below 9 years, those who have received any seasonal influenza vaccine before are recommended to receive one dose in the 2019-20 season.

32. If a child under the age of 9 years is getting seasonal influenza vaccine for the first time and requires 2 doses, does the same type of vaccine have to be used for both doses?

No, the first and second doses do not have to be the same type. However, the two doses should be separated by at least 4 weeks.

33. Can pneumococcal vaccines be given together with seasonal influenza vaccine?

Yes. Pneumococcal vaccines can be given with seasonal influenza vaccine at the same clinic visit, but should be administered with a different syringe and at a different injection site if inactivated influenza vaccine is used.

34. Can seasonal influenza vaccine be given together with Measles, Mumps and Rubella (MMR) vaccine?

Yes. Seasonal influenza vaccine can be given with MMR vaccine at the same clinic visit, but should be administered with a different syringe and at a different injection site if inactivated influenza vaccine (IIV) is used. IIV may be administered simultaneously or at any interval with MMR vaccine.  For individuals receiving live attenuated influenza vaccine, MMR vaccine not administered on the same day should be administered at least four weeks apart.

35. Can my child receive the seasonal influenza vaccination if he / she has received / will receive other immunisation?

Inactivated influenza vaccine (IIV) does not interfere with the effectiveness of other vaccines. It can be given at the same time or at different time with either inactivated vaccine (e.g. Hepatitis B vaccine) or live vaccine (e.g. Measles, mumps and rubella vaccine). Different vaccines should be given at different injection sites if IIV and other vaccines are given at the same time. For individuals receiving live attenuated influenza vaccine, other live vaccines not administered on the same day should be administered at least four weeks apart.

36. Why do some people who have been vaccinated still get influenza / influenza-like illness?

Influenza vaccines do not provide 100% protection against influenza, but they do reduce the risk of acquiring the disease as well as complications and death.  There are several reasons why someone may get influenza / influenza-like illness even after they have been vaccinated.  Firstly, the body takes about 2 weeks to develop antibodies after vaccination.  If infected before or shortly after vaccination, the protective effects of the vaccine may have not yet developed. Secondly, because it is not possible to predict exactly which strains of influenza virus will circulate in a given season, individuals may have exposed to a virus strain which is different from the vaccine strain, hence the vaccine does not provide protection.  Thirdly, there are other factors which will affect vaccine effectiveness including characteristics of the person being vaccinated (such as their age and health), and the similarity between the circulating viruses and the vaccine viruses. Finally, infections due to some other respiratory viruses may cause symptoms similar to influenza, and people may falsely believe that the vaccine failed to protect them.